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Even though it is less consumed, guarana (Paullinia cupana), native to the Amazon rainforest, contains one of the highest natural concentrations of caffeine (2.5% to 8.0% in dry weight) with a chemical profile also rich in phenolic compounds like theobromine, catechins and tannins.2 The tannins help to slow the release of caffeine into the bloodstream, resulting in a more prolonged stimulatory effect.3 This unique pharmacokinetic behavior has led to the widespread incorporation of guarana extract into energy drinks and fatigue-reducing supplements

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Methods We conducted a systematic review of studies from PubMed, Embase, and Cochrane databases (until November 2024), as well as relevant abstracts from Digestive Disease Week (DDW) 2024 and American College of Gastroenterology (ACG) 2024 to assess the impact of GLP-1 receptor agonists (GLP-1 RAs) on EGD

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