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Unlike conventional GLP-1 agonists that primarily target a single receptor pathway, GEP-44 functions as a triple agonist targeting GLP-1 and peptide YY receptors Y1 and Y2

Long-term success will depend on clinical differentiation, real-world evidence, payer value, patient support programs, adherence tools, physician education, and clear positioning across obesity, type 2 diabetes, cardiovascular risk and metabolic syndrome

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As we can see, the role of mitochondria regulation and cellular stress response stands at the center of many diseases

This perspective contrasts with failed targets , for which rigorous clinical evaluation has demonstrated unacceptable on-target toxicity or lack of efficacy at therapeutically relevant exposures