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Similarly, symptoms of gallbladder disease (such as right upper abdominal pain, fever, or jaundice) require prompt medical assessment, as GLP-1 medications may increase the risk of gallstone formation

doi: 10.1371/journal.pone.0168396

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Only 16 state Medicaid programs covered GLP-1s for obesity as of October 2025

Although no head to head trials comparing tirzepatide to semaglutide 2mg exists, an adjusted indirect treatment comparison study aimed to compare these two agents based on the results from SURPASS 2 and SUSTAIN FORTE

In addition, exendin 4 exerted renoprotective effects in animal models through inhibition of nuclear factor-B (NF-B) activity in the kidney, and elevated NF-B activity is known to contribute to the crosstalk between inflammation and oxidative stress 96