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The number that launched it came out of the semaglutide STEP 1 trial, where a body-composition substudy found that close to 40 percent of the weight people lost showed up as lean mass on the scan (Wilding et al., 2021)

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Regulatory Impact Analysis addressing global healthcare compliance, market access regulations, and evolving standards for pharmaceutical treatments in diabetes and obesity management

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doi: 10.2337/db10-0328 33 BergmanBCHowardDSchauerIEMaahsDMSnell-BergeonJKEckelRHet al