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Actual cost-sharing varies by plan, but beneficiaries can expect meaningful copays or coinsurance until they reach their out-of-pocket threshold

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The NEJM authors reported the most common side effects as mild-to-moderate gastrointestinal events, with the trial discontinued due to adverse events in 4.4% to 7.8% of participants receiving orforglipron compared to 1.4% given the placebo
