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Hageman PA, Mroz JE, Yoerger MA, Pullen CH

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Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation [see Drug Interactions (7.2), Use in Specific Populations (8.3), and Clinical Pharmacology (12.3)]

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Semaglutide significantly decreased glycated hemoglobin (A1C) levels compared with sitagliptin, liraglutide, exenatide ER and dulaglutide but adverse reactions (nausea, vomiting) were more likely to occur with semaglutide [12]

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