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Experimental evidence indicates that weight loss achieved through GLP-1 RAs is evaluated more negatively than lifestyle-based weight loss, reinforcing moralized distinctions regarding effort and legitimacy [86]

Persistent symptoms after four weeks warrant provider evaluation to rule out underlying GI conditions or medication interactions

If the medication causes nausea or fatigue, it may lead to a more sedentary lifestyle

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Cleveland Clinic Research Finds Injectable Medications for Obesity Produce Smaller Weight Loss in A Real-World Setting, Compared to Randomized Clinical Trials