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While GLP-1 and GIP reduce your intake (calories in), Glucagon increases your output (calories out)

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In the brain, insulin is more of a growth factor, says Christian Hlscher, a neuroscientist at the Henan Academy of Innovations in Medical Sciences and chief scientific officer at Kariya Pharmaceuticals, a drug company developing GLP-1 agonists to treat neurological diseases

Other combinations, such as GLP-1/gastrin co-agonists and GLP-1/GIP co-agonists, are also under development

P2Y12 receptor inhibitors such as clopidogrel or ticagrelor can be used, typically with a loading dose during the acute phase (aspirin 300 mg, clopidogrel 300600 mg, or ticagrelor 180 mg)

Some people try split dosing temporarily during dose escalation and then return to weekly dosing once they have adapted to their maintenance dose