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Doses, indications, and trial designs differ, but the headline pattern is consistent across multiple peer-reviewed analyses: higher GLP-1 dose drives higher GI rates, and adding GIP receptor activity (as tirzepatide does) appears to modestly buffer the diarrhea-specific signal compared to high-dose semaglutide alone

The mechanisms and cell types important for DPP-4mediated control of glucose and islet function have been extensively studied in humans and mice

Thats unclear and will depend on a few factors, experts say

GIP is involved in glucose and lipid metabolism, GLP-1 regulates insulin secretion and appetite, and GCG plays a role in fat breakdown for energy use

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