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DHEA-S binds more strongly to albumin, its carrier protein, than DHEA, thus contributing to the slower metabolic clearance from circulation [7]

The oral route of administration pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets and the drugs sensitivity to the heat required to compound it into a lozenge

Another consideration is the effect on weight and appetite

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Ruder K

Structural basis for activation of the growth hormone-releasing hormone receptor

Glyburide, a second-generation sulfonylurea, was previously considered for gestational diabetes but has fallen out of favor due to concerns about neonatal hypoglycemia and possible increased birth weight