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Zheng et al., 2009

Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial

Coping with Discomfort There are several strategies to cope with the discomfort of feeling cold

Fish: Fatty fish like salmon and mackerel contain good amounts of magnesium

DOI: 10.1016/S0140-6736(22)02597-1 Png ME, Harris V, Grabey J, et al

Some patients may respond well to lower-dose approaches, but most long-term clinical evidence is based on standard dosing protocols
