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Unlike earlier GLP-1 receptor agonists, retatrutide is a triple agonist : GLP-1 receptor agonist suppresses appetite, slows gastric emptying, improves insulin sensitivity GIP receptor agonist enhances insulin release, amplifies GLP-1 effects Glucagon receptor agonist stimulates energy expenditure, fat metabolism, and potentially impacts lipid handling Clinical trials so far have shown remarkable weight loss (up to 24% in some studies) and strong metabolic improvements, including effects on lipids like LDL cholesterol

Other aspects will also impact on clinical decision-making, for example, the injection preparation (problematic for exenatide ER and albiglutide) as well as the design of administration device, which may favour dulaglutide

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Research Article - (2024) Volume 16, Issue 6 Received: 09-Nov-2024, Manuscript No