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In the study SCALE (Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE - Obesity and Pre-diabetes), patients with obesity and pre-diabetes were randomized to once-daily subcutaneous injections of liraglutide at a dose of 3.0 mg or placebo

whereas, the ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathways are activated, accelerating muscle protein degradation [15]

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doi: 10.1016/j.peptides.2018.09.002 139 HuangJZhaoJGengXChuWLiSChenZJet al

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