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Think of it as a compounding effect

For example, over two years, total costs averaged ~$51,794 for surgical patients vs ~$63,483 for GLP-1 therapy

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In the brain, preproglucagon expressing neurons are localized to the brainstem in regions including the nucleus of the solitary tract (NTS) and ventrolateral medulla (Merchenthaler et al., 1999) and these neurons produce a number of peptides including GLP-1, oxyntomodulin, and glucagon-like peptide-2 (Holst, 2007)

The translation of these and other novel therapies under development into the clinical care of individuals with type 1 diabetes with established complications requires a concerted demonstration of efficacy and safety in dedicated and properly designed cardiorenal outcome trials