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recently analysed a cohort of 3737 patients with IBD and T2DM, demonstrating that the use of GLP-1RAs was associated with a 26% reduction in the risk of composite IBD outcomes, defined as steroid dependence, the initiation of advanced IBD therapy, hospitalization, surgery, or death (aHR: 0.74, 95% CI: 0.620.89) [32]

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These studies help clarify how peptide structure influences molecular recognition and interaction stability under defined laboratory conditions

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