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Per a 2021 analysis published in Diabetes Obesity Metabolism , nearly 50% of patients on semaglutide report nausea.41 Side effects tend to be dose dependent and may lessen in intensity with ongoing treatment.42,43 An underlying cause for these GI complaints relates to one of the ways in which GLP-1 medications work, which involves delayed gastric emptying

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The specific magnitude and speed of this regain with retatrutide are unknown
While body mass index (BMI), the most common measurement used to assess if a person is a healthy weight, is correlated with metabolic health in population studies, there are many people with a normal BMI with cardiovascular and metabolic issues, while many in the overweight and obese range are metabolically healthy

The interaction between gut flora and gut peptides provides a personalized approach to treat obesity and T2D