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From celebrities looking to drop a few pounds for the red carpet to people managing diabetes or obesity, GLP-1 drugs have become a popular weight management tool

The SURPASS-3 study was set up to investigate the efficacy and safety of tirzepatide versus a titration of the basal insulin degludec inadequately controlled by an oral therapy of T2D by metformin with or without an SGLT2 inhibitor comedication for 52 weeks (72)

But the body doesnt distinguish between a medication-induced caloric deficit and a famine

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Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: Systematic review and meta-analysis

After weighting the cohorts for inverse probability of treatment, the researchers found that, compared with second-line GLDs, ADRD risk was significantly lower with both GLP-1 receptor agonists (adjusted HR = 0.67