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2026 May 30;407(10544):2167-2179

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Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity onset diabetics

However, it is essential to continue monitoring as prescribed, particularly during dose escalation, to ensure glucose levels remain within target ranges

The fact that patients in this trial continued to lose weight after gastrointestinal adverse effects had subsided suggests that these effects were not the cause of weight loss