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Preguntas frecuentes Ozempic es adecuado para todos los pacientes con diabetes tipo 2

CHAKRABARTI: So Professor Holst, I wanted to ask you about this because there do seem to be the spectrum of intensity of side effects for these GLP-1 seems to be quite large, and the more and more people who come on it or who go on it and with staying on it for a longer period of time, are you concerned that we may start seeing side effects that are so severe that it would cast some doubt on the efficacy of GLP-1s

Obesity SURMOUNT-1 Trial In adults with obesity (without diabetes): Tirzepatide (15 mg) : 20.9% average body weight reduction over 72 weeks Semaglutide (2.4 mg) (based on STEP trials): ~14.9% average reduction STEP 5 Long-Term Results Semaglutide also demonstrated durable effects: At 104 weeks, patients maintained ~15% weight loss on semaglutide 2.4 mg (STEP 5) SELECT Trial Cardiovascular Benefit Semaglutide significantly reduced major adverse cardiovascular events by 20% in people with obesity and pre-existing heart diseaseindicating benefit beyond weight loss

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The average effective dose ranges from 1.0-2.4mg weekly, with higher doses associated with greater weight loss but increased side effects