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Description
Approval of GLP-1 RAs began with exenatide and liraglutide, followed by dulaglutide in 2014 and semaglutide in 2017
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Gastric distention activates satiety circuitry in the human brain
One hypothesis is that GLP-1 receptors in brain regions involved in the reward system could mediate direct effects on emotional regulation, impulsivity, or cravings
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