glp-1 agonists vs bariatric surgery weight loss comparison Newcastle bariatric surgery and glp 1

That year one in eight people were thought to be living with obesity around the world (WHO 2024)

GLP-1 receptor is expressed in human stomach mucosa: Analysis of its cellular association and distribution within gastric glands

Five clinical trials (SURPASS 1-5 trials) conducted in patients with T2DM showed that tirzepatide at 5-15 mg per week could reduce body weight (5.4-11.7kg), which was never seen with a single drug (129)

10.1186/s12885-023-11077-w 62 MadsenM

However, the potential for delaying or preventing the progression of T2DM in patients treated with GIP and GLP-1 remains uncertain, as there is currently no definitive evidence from human studies demonstrating that enhanced incretin activity directly affects -cell mass or alters the progressive loss of insulin secretory capacity in humans

JAMA Surg