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Brain struct Funct 226(1):225245 Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, Gospodarev V, Tang J, You C, Zhang JH (2018) Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

Used to characterise the pharmacodynamic consequences of C18 fatty diacid-albumin binding on GLP-1R engagement kinetics, receptor activation amplitude and duration, biased agonism profiles across Gs, Gq/11, and beta-arrestin signalling pathways, receptor internalisation and intracellular trafficking dynamics, and GLP-1R recycling versus lysosomal degradation under chronic long-acting agonist exposure

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Until additional data is available, a cautious approach is advisable

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doi: 10.1074/jbc.M109.073056