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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

Semaglutide was approved in 2017 as Ozempic for diabetes, and in 2021 as Wegovy for obesity

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Doses of liraglutide previously shown to have efficacy in AD and PD mouse models were used