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Description
In the additional analysis comparing the GLP1 receptor agonist group with the SGLT2 inhibitor group, the hazard ratio for thyroid cancer was 1.16

However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics

ARB, angiotensin II receptor blocker

While Tirzepatide is generally well tolerated, it may cause side effects such as nausea, diarrhea, and decreased appetite, which are typically mild to moderate

Metabolic side effects : Can raise cholesterol and blood sugar, potentially worsening heart disease risk if unmanaged

There is also an urgent need for standardized clinical outcome measures that encompass both the motor and non-motor symptoms of PD, as well as the metabolic parameters relevant to T2DM
