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In the additional analysis comparing the GLP1 receptor agonist group with the SGLT2 inhibitor group, the hazard ratio for thyroid cancer was 1.16

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However, despite previous reports on the potential advantage posed by GLP1-based multi-agonists in the management of obesity and metabolic disease, as recently exemplified by the dramatic body weight-lowering actions of the GLP1/GIP dual agonist, tirzepatide 47 , to our knowledge, no study has addressed to date the pharmacological characterization of GLP1-based unimolecular multi-agonists for management of reproductive and metabolic alterations of PCOS, using suitable preclinical models, as pre-requisite for their application in clinics

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ARB, angiotensin II receptor blocker

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While Tirzepatide is generally well tolerated, it may cause side effects such as nausea, diarrhea, and decreased appetite, which are typically mild to moderate

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Metabolic side effects : Can raise cholesterol and blood sugar, potentially worsening heart disease risk if unmanaged

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There is also an urgent need for standardized clinical outcome measures that encompass both the motor and non-motor symptoms of PD, as well as the metabolic parameters relevant to T2DM

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