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BMJ, 2020

In people who develop hyperglycemia on statinsor who begin with pre-diabetesconsider therapies that enhance GLP-1 signaling (GLP-1 receptor agonists, DPP-4 inhibitors) or improve insulin sensitivity (metformin) while continuing evidence-based lipid lowering

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Disease Modification Potential While GLP-1 medications dont cure diabetes, they may modify disease trajectory: Preserved beta cell function: Some evidence suggests GLP-1 medications may help preserve pancreatic beta cells, potentially slowing disease progression

GLP-1 receptors in the intestine shift fluid and electrolyte handling and can speed colonic transit, even while the stomach empties more slowly