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As interest has grown, so has the surrounding commercial ecosystem

In the Phase 2 clinical trial published in The New England Journal of Medicine in 2023, gastrointestinal side effects affected the majority of participants, with nausea, vomiting, diarrhea, and constipation being the most frequent complaints

The difference in outcome often reflects individual tolerability and adherence rather than absolute dose superiority

PubMed/MEDLINE, Embase, Scopus, Web of Science Core Collection, and ClinicalTrials.gov were searched from inception to March 1, 2026

The request was made because safety clinical trials of the medication revealed an increased occurrence of pancreatic, colorectal, and lung cancer with this drug

Supplementation: Begin magnesium glycinate 200 mg at bedtime, B-complex vitamin with breakfast, and vitamin D3 2,000 IU daily