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and high-frequency synaptic transmission imposes further metabolic burdens [63]

Trial data have shown decreases in serious cardiovascular complications, including cardiovascular mortality, nonlethal heart attacks, and nonfatal cerebrovascular accidents, among individuals with type 2 diabetes and pre-existing cardiovascular pathology or high cardiovascular risk [3,5,13,14,37]

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Sensitivity analyses We conducted two sensitivity analyses to ensure the robustness of our findings due to the heterogeneous nature of adverse CVEs

Macro vascular complications are still the primary cause of death in patients with T2DM.Glucagon like peptide-1 receptor agonists (GLP1-RAs) are a new class of Injectable Anti-diabetes Agents (IADA) that provides blood glucose control with weight reduction ability, systolic blood pressure reduction and a noticeable improvement of lipid profile