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It is important to note that an impact of the Inflation Reduction Act is that small molecule therapeutics may continue to be deprioritized in favor of biologics, so development of oral biologics may (unfortunately) be more compelling for companies in this context

V.et al (2024)

In db/db mice, A 1-42 -treated mice or hTauP301L mice, liraglutide alleviated tau hyperphosphorylation, and prevented dysregulation of Akt and GSK-3 in brain (161, 163, 164)
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This gap has practical implications
