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Eighth, the efficacy of GLP-1 RAs in non-obese or non-diabetic KOA patients warrants further investigation

Turton MD, O'Shea D, et al

TrumpRx US GLP-1 Deal: Limited Spillover for Canadian Prices US TrumpRx program starts GLP-1 prices at US$350 dropping to US$245, but Canadian prices are already lower and generic semaglutide is reshaping the market

As per Bradford Hills criteria 41 , the biological plausibility through GLP-1R expression in the nervous system and temporal consistency in time-to-onset analysis support potential causality, but confounding factors inherent to spontaneous reporting systems preclude definitive conclusions

In knee OA, clinical data suggest that GLP-1RAs improve pain and function and reduce the risk of surgical intervention