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However, the native GLP-1 peptide has a very short half-life of approximately 12 minutes, as it is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), which limits its direct therapeutic potential

Maintaining dietary adherence is one of the strongest predictors of long-term weight management success, and if a zero-calorie alternative helps someone reduce overall energy intake without feeling deprived, it may have a legitimate role within a broader calorie-controlled plan

RCT: randomized controlled trial

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Compounded tirzepatide is not the same as Mounjaro or Zepbound, and it should not be described as a generic version of either

Pubmed Central PMCID: 4528846