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The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)

There are currently four popular GLP-1 agonists approved by the FDA (two FDA-approved agonists, lixisenatide and exenatide, have been discontinued in recent years)

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Desai and Levine reported that weight reductions in GLP-1 RA users were comparable to those observed in non-IBD matched controls [29,36], with greater reductions observed with Tirzepatide [29]

3) Relative expression of perilipin genes Perilipin family proteins, with five recognized members (PLIN1-5), are found on the surfaces of intracellular lipid droplets 46