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Importantly, considering the preclinical evidence indicating that these compounds might hinder bone formation by engaging with YR2 within the hypothalamus, it becomes imperative to investigate the impact of PYY analogs on human osteoblasts both in vitro and in vivo

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He noted that the 4 mg dose achieved nearly 20% weight loss with one escalation step, while the 12 mg dose delivered a level of weight loss long associated with bariatric surgery. He added that retatrutide could support a more patient-centric approach to treating obesity

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