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La tirzepatida (15 mg una vez a la semana), un agonista dual que acta sobre los receptores GLP-1 y GIP, produjo una prdida de peso de hasta el 17,8% despus de 72 semanas , y la semaglutida (2,4 mg una vez a la semana) produjo una prdida de peso de hasta el 13,9% despus de 68 semanas, ambas en comparacin con placebo