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Greater mortality in the metformin group: how results differed between the 2022 paper by Keys and the 2014 Banner paper [40:00]

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3.2 Lactic acidosis During metformin treatment, plasma lactate concentration increases with enhanced glucose uptake in the intestine, resulting in side effects in some patients with one or more risk factors for lactic acidosis (Misbin et al., 1998

For individuals with visceral adiposity related to specific medical conditions, specialist referral is the appropriate pathway rather than self-directed use of unlicensed agents

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This percentage increases to 40% among those who intend to take the drug in the future