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For inhalers, another class of drug-device combination products, the median number of patents at FDA approval has steadily increased from 2 (for inhalers approved 1986-1997) to 8 (1998-2008) to 11 (2009-2020), with more than half of these patents covering inhaler delivery devices

The risk magnitude rises with the severity of liver disease in NAFLD, particularly at higher fibrosis stages [42]

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However, like all medications, they can cause side effects

In phase 3 trials, peak increases in serum creatinine were observed after 4 to 8 weeks of treatment

Statements Author contributions J-YW and Q-WW wrote the first draft of the manuscript