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Using an integrated ligand and structure-based virtual screening pipeline, explicitly combining complementary ligand-based descriptors, multi-fingerprint similarity, electrostatic similarity, pharmacophore modeling, and multi-conformation docking under a consensus-driven selection strategy, we were able to identify three chemically distinct classes of GLP-1R agonist candidates: GQB47810, a non-peptidic molecule

When employees would trade vacation time, remote work days, or even part of their bonus for GLP-1s, there should be real consideration for plans which is a better investment for their business

GLP-1 medications may increase kidney stone risk through dehydration and uric acid changes, but individual risk depends on baseline kidney function, hydration status, and metabolic factors

A consensus clinical practice recommendation endorsed by the Australian Diabetes Society (ADS), National Association of Clinical Obesity Services (NACOS), Gastroenterological Society of Australia (GESA) and Australian and New Zealand College []

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