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However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Nuijten M.A.H., Eijsvogels T.M.H., Monpellier V.M., Janssen I.M.C., Hazebroek E.J., Hopman M.T.E

Small, frequent sips throughout the day may be better tolerated than large volumes at once, given the delayed gastric emptying associated with GLP-1 therapy

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This framing is uncomfortable for many people who view medication as something you take temporarily until a problem resolves, but it aligns with the biological reality of obesity as a chronic disease with chronic neurohormonal underpinnings