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However, the incidence of gastrointestinal events, discontinuations due to adverse events, and mean increase in pulse rate were higher with orforglipron than oral semaglutide

Some patients report feeling unusually cold during their first weeks of treatment, a symptom tied directly to decreased caloric intake and changes in thermogenic (heat-producing) pathways

They dont replace these medications, but the required dose may go down

Both Wegovy and Zepbound use gradual escalation approaches partly because tolerability matters

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That translates to a 65% reduction in thyroid cancer incidence among tirzepatide users compared to matched controls