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Among the GLP-1 analogs, tirzepatide showed the most pronounced decrease in respiratory quotient (RQ) (Fig

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Serious but rare risks include pancreatitis, gallbladder disease, and acute kidney injury secondary to dehydration, requiring patients to report persistent symptoms promptly to their healthcare provider

69,70 Recent evidence suggests a central nervous system component, as a modified exenatide with reduced brain penetration caused less vomiting in animal models while preserving glucose-lowering effects

However, like any medication, semaglutide does come with potential side effects