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A 2023 systematic review found mixed evidence, but several small trials showed modest symptom improvement when started before or alongside semaglutide

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In one study cited on DrugWatch, researchers noted that GLP-1 receptor agonists were linked with higher rates of upper gastrointestinal tract disorders compared with other types of diabetes medication but called for further research given limitations inherent in observational studies

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However, treatment discontinuation due to adverse events occurred in 24.6% and 3.9% of participants, respectively, mainly due to gastrointestinal adverse events