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Semaglutide (Ozempic) targets one receptor pathway (GLP-1), while Tirzepatide (Mounjaro) targets two (GIP and GLP-1)

Some patients also benefit from creatine supplementation, which has an excellent safety profile and supports muscle maintenance

Whey or plant based protein powders provide concentrated nutrition without excessive volume that triggers nausea

Knockdown of GLP1 receptors within the CNS also failed to alter baseline blood glucose levels (Table 2), supporting a principal action for GLP1 in the periphery for proper basal glycaemic control (Sisley et al., 2014)

With the availability of extended-release medications, daily dosing is rarely recommended

Methods We identified genetic proxies of the effect of GLP-1R, GIPR, and GCGR by combining Mendelian randomization (MR), Bayesian colocalization, and linkage disequilibrium (LD) analyses