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It plays a key role in post-meal glucose control by increasing insulin secretion and suppressing glucagon levels

The SCALE trials showed liraglutide 3.0 mg producing approximately 8% body weight loss over 56 weeks, roughly half of what semaglutide achieves

Lipogenesis is the metabolic process where the body converts excess calories into stored fat

in clinical trial results reported in December, retatrutide led to average loss of up to 29% of participants body weight after 68 weeks, or about 71 pounds, in a study of people with knee osteoarthritis

In contrast, GLP-1 RAs such as tirzepatide had ICERs approaching $197,000 per QALY in some models [8], well beyond typical WTP thresholds used in health policy evaluations

For patients on exogenous glucocorticoid therapy, there is profound suppression of POMC production and hence, MSH production