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tirzepatide cardiovascular outcome trial and Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management SURPASS-CVOT Published: Large Trial Confirms
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Very positive experience

Epub 2023 Aug 1

If you travel across time zones, timing becomes more nuanced

However, many people tolerate both medications well, and individual response varies significantly

More clinical outcome data will become available over the medium term for oral semaglutide (ASCEND PLUS trial) and the nonpeptide oral GLP-1 receptor agonist orforglipron (ACHIEVE-4) (90) (Table 1)

Individualised dose adjustment or alternative treatment options may be considered where necessary
