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The Mayo Clinic notes that while GLP-1 medications have helped many patients (often with diabetes) lose weight, researchers continue to study potential long-term effects, including loss of muscle mass, reduced bone density and other health impacts that may emerge with prolonged use

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Representative Western blot and normalized densitometric analysis ( n = 3/group) show that GLP-1(2836) prevented activation of cleaved caspase-3 in the presence of H 2 O 2 versus controls