abbvie glp-1 receptor agonist weight management diabetes treatments What's New in Obesity Treatment? Glucagon-like peptide-1 receptor agonists and

doi: 10.1038/ijo.2015.172 17 DeaconCFHolstJJ

GIP and GLP1 exert their effects by binding to their specific receptors, the GIP receptor (GIPR) and the GLP1 receptor (GLP1R), which belong to the Gprotein coupled receptor family

Yet 6 to 7 weeks of daily treatment with semaglutide (escalated from 41 g/kg to 103 g/kg) or tirzepatide (escalated from 12 g/kg to 48 g/kg) did not produce any noticeable effect on these readouts, including Iba-1 activation, in 12-month-old 5XFAD and APP/PS1 mice (51)

The study was sponsored by Eli Lilly and Company, the manufacturer of orforglipron and the injectable GLP-1 tirzepatide

declares no conflict of interest

GLP-1 receptor agonist drugs (e.g., semaglutide, liraglutide, tirzapeptide) work by mimicking natural GLP-1 but last much longer