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Although the cardioprotective effects of GLP-1RA are more established in atherosclerotic cardiovascular disease than in heart failure, recent studies demonstrate a modest but clinically meaningful benefit in heart failure with preserved ejection fraction (HFpEF), particularly among obese patients
10.1007/s00795-013-0053-9 [DOI] [PubMed] [Google Scholar] 163.Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, et al
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The observed benefits may stem from correcting underlying cardiometabolic dysfunction One of the primary mechanisms of GLP-1 receptor agonists is the modulation of insulin metabolism
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