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Hong C-T, Chen K-Y, Wang W, Chiu J-Y, Wu D, Chao T-Y, et al

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Insulin-degrading enzymes (IDEs) are enzymes used to break down insulin and IGF-1, removing A 40 and A 42 monomers but not affecting A oligomers or fibers (Kemeh and Lazo, 2023)

The N-terminal region of tirzepatide (residues 1 to 10) in GIPR and GLP-1R overlapped well with the formation of a network of extensive interactions with multiple conserved residues (Y 1.43b , Y 1.47b , R190/K197 2.67b , Q 3.37b , V 3.40b , N290/N300 ECL2 , R 7.35b and I378/L388 7.43b ) (Fig

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