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Description
Boxed warning class effect: contraindicated in clients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for the treatment of type 2 diabetes and obesity, may modulate pathways associated with the hallmarks of aging

taking GLP-1 drugs

Methotrexate No direct interaction exists between tirzepatide and methotrexate

These criteria are narrower than the general obesity indication that many commercial plans previously covered

Results may vary based on starting weight, program adherence, and individual health factors
