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Description
We demonstrate that the therapeutic potential of GLP-1RAs in RA is mediated by their dual targeting of two key pathological pathways: suppressing a previously unidentified cGAS-STING-ferroptosis axis in chondrocytes and reprogramming synovial macrophages toward an M2 reparative phenotype, which collectively helps maintain joint homeostasis
The FDA has stated that semaglutide and tirzepatide do not currently appear on the 503B bulks list or the FDA drug shortage list, and the agency has proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list
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Practice points for managing DKD are summarised in Box 4
Exposure to excessive heat or freezing temperatures can denature the protein-based medication, rendering it ineffective
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