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Adverse event reporting Adverse events were recorded as was drug compliance (unused medication in the injector pens documented)

Metformin is generally weight-neutral or causes slight weight loss

[15] In January 2022, Wegovy was approved for medical use in the European Union

Significant weight loss can reduce BMD, which may influence fracture risk, regardless of the medication used

Humphrey CD, Lawrence AC

Quantification of hepatic triglycerides Livers were homogenized in triglyceride assay buffer and triglycerides were measured using the Triglyceride quantification Assay Kit (Abcam) according to the manufacturers instructions